Sodium bis(trimethylsilyl)amide solution 1.0 M in THF
Sodium bis(trimethylsilyl)amide solution (NaHMDS) is widely used as a strong base in organic synthesis for deprotonation reactions and base-catalyzed reactions. It is also involved in the generation of enolates, Wittig reagents and carbenes.[2][3]
NaHMDS can be used as a base:
• In the synthesis of N-boc-1-amino-1,3-diene derivatives from N-boc-1-amino-4-methoxy-2-
• To deprotonate
alkyl or aryl ketones to generate enolate derivatives by hydroxylation reaction.[4]
• In the enantioselective synthesis of 1,2-amino alcohols by the reaction between various nitroalkanes and aldehydes via nitroaldol
reaction promoted by bimetallic heterogeneous catalyst.[5]
18, 20 L in steel drum
4×25, 100, 4×100, 800 mL in Sure/Seal™
The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.
Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
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