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Antibiotic Antimycotic Solution (100×), Stabilized with 10,000 units penicillin, 10 mg streptomycin
Antibiotic antimycotic solution has been used as a supplement in different types of cell culture media.[2][1][3]
This solution is formulated to contain 10,000 units penicillin, 10 mg streptomycin and 25μg Amphotericin B per mL, and is solubilized in a proprietary citrate buffer. It is recommended for use in cell culture applications at 10mL/L.
Mode of Action: Penicillin acts by inhibiting bacterial cell-wall synthesis. Streptomycin inhibits prokaryote protein synthesis by preventing the transition from initiation complex to chain-elongating ribosome and causes miscoding. Amphotericin B interferes
with fungal membrane permeability by forming channels in the membranes and causing small molecules to leak out.
Antimicrobial spectrum: Includes Gram-negative bacteria, Gram-positive bacteria, fungi and yeasts.
